AANS Neurosurgeon | Volume 27, Number 1, 2018


New Epilepsy Drugs Work by Jamming Brain Receptor

Details from study in rat brain cells could lead to more effective antiepileptic drugs with fewer side effects

Columbia University Medical Center (CUMC) researchers have discovered how a new epilepsy drug works, which may lead the way to even more effective and safer medications. The most commonly used anti-epilepsy drugs are ineffective for about 30 percent of people with seizure disorders. A new direction in the treatment of epilepsy is aimed at inhibiting AMPA receptors, which help transmit electrical signals in the brain and play a key role in propagating seizures. Currently, perampeanel is the only FDA-approved drug that targets AMPA receptors. But because perampanel is associated with significant side effects, its clinical use has been limited. To read more, click here.


Second International Brain Mapping Course
April 26-27, 2018; New Orleans

Surgical Approaches to Skull Base
April 26-28, 2018; St. Louis, MO

2018 AANS Annual Scientific Meeting
April 28-May 2, 2018; New Orleans

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