AANS Neurosurgeon | Volume 26, Number 4, 2017

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Neuroscientists Find Promise in Intervention to Normalize Biological Functions in Fragile X Mice

A team of neuroscientists have developed an intervention that normalizes multiple biological functions in mice afflicted with Fragile X Syndrome (FXS). Its breakthrough centers on protein synthesis, or the building of proteins, and actin dynamics, which help regulate cellular processes—two functions that are inhibited in individuals with FXS.

“Our findings are consistent with the idea that an imbalance of protein synthesis and actin dynamics contribute to physiological problems in FXS mice,” explains New York University Professor Eric Klann, director NYU’s Center for Neural Science and the study’s senior author. “Moreover, they offer a potential approach to treating individuals with Fragile X syndrome: targeting a specific protein, eIF4E, that regulates protein synthesis.”

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