AANS Neurosurgeon | Volume 27, Number 2, 2018


Mount Sinai Researchers Identify Brain Insulin Resistance as Possible New Link Between Alzheimer's Disease and Diabetes

Many studies link the development of Alzheimer’s disease as an increased risk for patients who have been diagnosed with diabetes. However, in a new study from the Icahn School of Medicine at Mount Sinai suggests the reverse. Alzheimer’s disease impairs insulin signaling in the the portion of the brain that is responsible for regulating a patient’s metabolism. As a result, this increases the change that the patient has a greater chance of developing diabetes. “This is the first study to suggest that Alzheimer’s disease pathology increases susceptibility to diabetes due to impaired insulin in the hypothalamus,” said Christoph Buettner, MD, PhD, associate professor of medicine, Endocrinology, Diabetes, Bone Disease and Neuroscience, Icahn School of Medicine at Mount Sinai, and lead author of the study. “Our research provides a rationale that therapies developed to improve insulin signaling in the brain may reduce the likelihood that a patient with Alzheimer’s disease develops diabetes.” To read more on this study, click here

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