AANS Neurosurgeon | Volume 27, Number 2, 2018


Cerebrospinal Fluid Signals Control the Behavior of Stem Cells in the Brain

In this study, researches from Biozentrum, University of Basel found that the choroid plexus produces signals that regulate adult neural stem cells. Within the brain, these neural cells give rise to neurons throughout life. They also provide key signals that regulate cell self-renewal and differentiation. Within the findings, researchers identified that the choroid plexus secretes a wide variety of signaling factors in the cerebrospinal fluid (CSF), which are important for stem cell regulation. Furthermore, they found that although stem cells are present throughout aging, the signals they receive from the choroid plexus changes making them divide less. “One reason is that signals in the old choroid plexus are different. As a consequence, stem cells receive different messages and are less capable to form new neurons during aging. In other words, compromising the fitness of stem cells in this brain region,” explains Violeta Sliva Vargas, the first author of the study. To read more, click here.

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