Experimental Therapy Halts Treatment-resistant Brain Tumors
Researchers report lab breakthrough in human cells, mouse models for high grade gliomas
The protein encoded by the Olig2 gene is present in a vast majority of gliomas. Researchers have found that using a gene therapy can halt the growth of gliomas in both human cells and mouse models. Removing the Olig2 gene stops further tumor grown. Even further, removing or eliminating the Olig2-producing cells block any type of tumor formation. “We find that elimination of dividing Olif2-expressing cells block initiation and progression of glioma in animal models and further show that Olig2 is the molecular arbiter of genetic adaptability that makes high-grade gliomas aggressive and treatment resistant,” said Qing Richard Lu, PhD, lead investigator and scientific director of the Brain Tumor Center at Cincinnati Children’s. “By finding a way to inhibit Olig2 in tumor forming cells, we were able to change that tumor cells’ makeup and sensitize them to targeting molecular treatment. This suggests a proof for stratified therapy in distinct subtypes of malignant gliomas.” To read more, click here.
GOODMAN Oral Board Preparation Course Tumor
Nov. 1-3, 2017; Glendale, Ariz.
June 29-30, 2017; Germany
2nd International Conference on Spine and Spinal Disorders
July 24-26, 2017; Rome, Italy
The Society of University Neurosurgeons Annual Meeting
July 27-Aug. 3, 2017; South Africa
Washington University/St. Louis Children’s Comprehensive SEEG Course
Aug. 10-12, 2017; St. Louis