AANS Neurosurgeon | Volume 27, Number 2, 2018

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Experimental Drug Blocks Toxic Ion Flow Linked to Alzheimer’s Disease

An international team of researchers has shown that a new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer’s disease. The drug works by stopping toxic ion flow in the brain that is known to trigger nerve cell death. Scientists envision that this drug could be used to treat Alzheimer’s and other neurodegenerative diseases such as Parkinson’s and ALS.

“This is the first drug molecule that can regulate memory loss by directly blocking ions from leaking through nerve cell membranes,” said Ratnesh Lal, a professor of bioengineering at the University of California San Diego and co-senior author of the study.

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