You are viewing AANS Neurosurgeon Volume 26, Number 1, 2017. View our current issue, Volume 26, Number 4, 2017

AANS Neurosurgeon | Volume 26, Number 1, 2017

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Drug Improves Brain Performance in Rett Syndrome Mice

After learning that a small-molecule drug improves breathing in a mouse model of the neurodevelopmental disorder Rett syndrome, University of Alabama at Birmingham researcher Lucas Pozzo-Miller, Ph.D., wondered if he could test it on other brain functions.

Pozzo-Miller has now found that the brain penetrant drug — a small-molecule mimetic of BDNF, or brain derived neurotrophic factor — is able to improve brain performance in Rett syndrome mice — specifically synaptic plasticity in the hippocampus and object location memory. The hippocampus is involved in learning and memory.

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Calendar/Courses

Spine World Summit
Jan. 26, 2018 - Jan. 27, 2018; Hong Kong

6th Ottawa Neurosurgery Review Course
Feb. 3, 2018 - Feb. 10, 2018; Ottawa, ON Canada

Winter Clinics for Cranial and Spinal Surgery
Feb. 25, 2018 - Mar. 1, 2018; Snowmass Village, Colo.

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