Discovery of a Promising Medication for Amyotrophic Lateral Sclerosis (ALS)
Experiments conducted on worms, zebrafish, mice and, finally, on human subjects in a limited clinical trial conclude that pimozide may be effective in treating what’s known as “Lou Gehrig’s disease.”
Researchers from the University of Montréal Hospital Research Centre (CRCHUM) and the Cumming School of Medicine (CSM) at the University of Calgary have discovered a medication that could make it possible to treat individuals with amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease.
An article published today in JCI Insight concludes that pimozide was found to be safe and over the short term, preliminary data shows that it could stabilize the progression of ALS. This neurodegenerative disease normally leads to a progressive paralysis of the skeletal muscles and, on average, three years after the onset of symptoms, to death.
“This medication alleviates the symptoms of ALS in animal models,” said Alex Parker, a CRCHUM researcher and professor at Université de Montréal. “Riluzole and edaravone, the drugs currently used, have modest effects. Other studies must be conducted to confirm our results, but we believe that we’ve found a medication that may prove to be more effective in improving patients’ quality of life.”
Click here to read more.
1st Annual Aspen Conference on Pediatric Cerebrovascular Disease and Stroke
July 16-20, 2018; Snowmass Village, CO
2018 Neurosafe Symposium
August 2-3, 2018; Minneapolis
2018 Tennessee Neurological Society Annual Meeting
August 3-4, 2018; Franklin, TN
2018 From Cranial to Spine: An Overview of Neurological Topics for the Advanced Practice Provider
August 8-11, 2018; Los Angeles
2018 Managing Coding and Reimbursement Challenges
August 9-11, 2018; Chicago