AANS Neurosurgeon | Volume 26, Number 1, 2017

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Depriving Deadly Brain Tumors of Cholesterol May be Their Achilles' Heel

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In mouse models, alternative approach proves promising against hard-to-treat cancer

Researchers at the University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models. The findings also present a potential alternative method for treating glioblastomas (GBM), the most common and most aggressive form of brain cancer. GBMs are extremely difficult to treat. The median survival rate is just over 14 months, with few treated patients living five years or more past diagnosis. Click here to read more.

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