AANS Neurosurgeon | Volume 26, Number 3, 2017

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DAWN Trial Results Demonstrate Dramatic Reduction in Disability From Stroke Up to 24 Hours of Onset

Mechanical removal of blood clot plus medication found to be better than medication alone; University Hospitals Cleveland Medical Center part of trial 

Results from the DAWN stroke trial presented at the European Stroke Organization Conference (ESOC) provide compelling evidence that selected patients suffering a major ischemic stroke recovered significantly better with mechanical retrieval of the blood clot with medical therapy compared with medical therapy alone when initiated past the current guidelines of within six hours and up to 24 hours of the stroke. University Hospitals Cleveland Medical Center was one of the top seven recruiting sites in the multi-site study that enrolled a total of 206 patients in the nation. The results showed that patients treated with the retrieval system, known as mechanical thrombectomy, had significantly decreased post-stroke disability and improved functional independence at 90 days compared to medical management alone. “This is incredible,” said Cathy Sila, MD, Director of UH’s Comprehensive Stroke Center, and principal investigator of the study at the UH site. “Almost half of the patients (48.6 percent) receiving the thrombectomy therapy had a good outcome at 90 days after treatment — defined as the patients being independent in activities of daily living — as opposed to only 13.1 percent of the patients treated medically or with clot-busting drugs alone. This 35 percent difference may be higher than any level of benefit from any stroke trial.” 

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