AANS Neurosurgeon | Volume 27, Number 1, 2018

Combination Therapy May Be Better Than Radiotherapy Alone to Treat Aggressive Brain Cancer

| Newsline

While radiotherapy effectively damages brain tumors, the cancer cells within these tumors can repair themselves in order to live on. However, researchers from the Sidney Kimmel Cancer Center tested a new combination of radiotherapy and drugs that stop the tumors from mending themselves after being hit with radiation. While they have only completed phase 1, their results are promising enough to begin phase 2 to continue testing the combination therapy for aggressive and recurrent brain cancer. “We saw synergy between radiotherapy and the agent, panobinostat. Our findings suggest panobinostat makes radiotherapy much more effective,” says the study’s senior author, Yaacov R. Lawrence, MD, of the Department of Radiation Oncology at Thomas Jefferson University’s Sidney Kimmel Medical College. Click here to read more.

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