AANS Neurosurgeon | Volume 26, Number 4, 2017


Caffeine-based Compounds Show Promise Against Parkinson's Disease

Compounds prevent key protein from mis-folding, preventing death of dopamine-producing brain cells

A teem of researchers from the University of Saskatchewan has developed two caffeine-based chemical compounds that show promise in preventing the ravages of Parkinson’s disease. 

Parkinson’s disease attacks the nervous system, causing uncontrolled shakes, muscle stiffness and slow, imprecise movement, chiefly in middle-aged and elderly people. It is caused by the loss of brain cells (neurons) that produce dopamine, an essential neurotransmitter that allows neurons to “talk” to each other. The team focused on a protein called a-synuclein (AS), which is involved in dopamine regulation.

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Winter Clinics for Cranial and Spinal Surgery
Feb. 25, 2018 - Mar. 1, 2018; Snowmass Village, Colo.

69th Southern Neurosurgical Society Annual Meeting
Feb. 28, 2018 - Mar. 3, 2018; San Juan, PR

Second International Brain Mapping Course
April 26-27, 2018; New Orleans

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