AANS Neurosurgeon | Volume 26, Number 2, 2017

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Blocking Inflammation Prevents Cell Death, Improves Memory in Alzheimer's Disease

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University of California, Irvine (UCI) neurobiologists have disarmed the brain’s response to plaques that are the hallmark of Alzheimer’s disease. Kim Green and colleagues with UCI’s Institute for Memory Impairments and Neurological Disorders flushing out the inflammatory cells restored memory function in test mice. These cells, called microglia, contribute to neural deficits, such as memory, that can be seen in this neurodegenerative disease. “Our findings demonstrate the critical role that inflammation plays in Alzheimer’s-related memory and cognitive losses,” said Green, an assistant professor of neurobiology & behavior. “While we were successful in removing the elevated microglia resulting from beta-amyloid, further research is required to better understand the link among beta-amyloid, inflammation and neurodegeneration in Alzheimer’s”. To read more, click here

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